Diagnosis of left ventricular hypertrophy using non-ECG-gated 15O-water PET.
J Nucl Cardiol
; 29(5): 2361-2373, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-34286452
ABSTRACT
AIM:
To develop a method for diagnosing left ventricular (LV) hypertrophy from cardiac perfusion 15O-water positron emission tomography (PET).METHODS:
We retrospectively pooled data from 139 subjects in four research cohorts. LV remodeling patterns ranged from normal to severe eccentric and concentric hypertrophy. 15O-water PET scans (n = 197) were performed with three different PET devices. A low-end scanner (66 scans) was used for method development, and remaining scans with newer devices for a blinded evaluation. Dynamic data were converted into parametric images of perfusable tissue fraction for semi-automatic delineation of the LV wall and calculation of LV mass (LVM) and septal wall thickness (WT). LVM and WT from PET were compared to cardiac magnetic resonance (CMR, n = 47) and WT to 2D-echocardiography (2DE, n = 36). PET accuracy was tested using linear regression, Bland-Altman plots, and ROC curves. Observer reproducibility were evaluated using intraclass correlation coefficients.RESULTS:
High correlations were found in the blinded analyses (r ≥ 0.87, P < 0.0001 for all). AUC for detecting increased LVM and WT (> 12 mm and > 15 mm) was ≥ 0.95 (P < 0.0001 for all). Reproducibility was excellent (ICC ≥ 0.93, P < 0.0001).CONCLUSION:
15O-water PET might detect LV hypertrophy with high accuracy and precision.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Agua
/
Hipertrofia Ventricular Izquierda
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article