Trends in patent ductus arteriosus ligation in neonates and changes in outcomes: A 10-year multicenter experience.
Pediatr Pulmonol
; 56(10): 3250-3257, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34288596
ABSTRACT
RATIONALE The management of neonates with patent ductus arteriosus (PDA) has changed over time. METHODS:
We conducted a single-city, retrospective review of neonates who underwent PDA ligation over a 10-year time period and compared infants from the first 5 years to the second 5 years to evaluate how clinical characteristics changed over this time.RESULTS:
Infants from the second 5-year epoch were older at time of ligation (38 vs. 30 days), had a higher ligation weight (1432 vs. 1121 g) and a lower incidence of postligation cardiac syndrome (1.9% vs. 11.5%). No differences in mortality, length of hospital-stay or major morbidities were seen. Compared to neonates who underwent PDA ligation at ≤28 days of life, those with a ligation age >28 days had a higher ligation weight (1421 vs. 1039 g), a higher proportion of COX inhibitor use (92.5% vs. 83.8%), and a higher incidence of moderate-severe bronchopulmonary dysplasia (BPD) (60.4% vs. 44.4%). Only 10.7% (25/233) patients were evaluated by laryngoscopy, in which the incidence of vocal cord paralysis (VCP) was 36.0%; 2 patients were clinically diagnosed with VCP for a total 4.7% incidence of VCP (11/233).CONCLUSIONS:
Over the 10 years examined, neonates underwent PDA ligation at an older age in the second 5-year time period; this change was not associated with a change in the incidence of major morbidities. Ligation age >28 days was associated with an increase incidence of moderate-severe BPD. The overall incidence of documented VCP post-PDA ligation was relatively low but was seen in over 1/3 who were evaluated by laryngoscopy.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Parálisis de los Pliegues Vocales
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Conducto Arterioso Permeable
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
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Humans
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Infant
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Newborn
Idioma:
En
Año:
2021
Tipo del documento:
Article