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Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus.
Spanò, Barbara; Nardo, Davide; Giulietti, Giovanni; Matano, Alessandro; Salsano, Ilenia; Briani, Chiara; Vadalà, Rita; Marzi, Claudia; De Luca, Maria; Caltagirone, Carlo; Santangelo, Valerio.
Afiliación
  • Spanò B; Neuroimaging Laboratory, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Via Ardeatina 306, 00179, Rome, Italy. b.spano@hsantalucia.it.
  • Nardo D; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
  • Giulietti G; Neuroimaging Laboratory, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Via Ardeatina 306, 00179, Rome, Italy.
  • Matano A; Neuropsychology Center, Santa Lucia Foundation IRCCS, Rome, Italy.
  • Salsano I; Neuroimaging Laboratory, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Via Ardeatina 306, 00179, Rome, Italy.
  • Briani C; PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Rome, Italy.
  • Vadalà R; Neuroimaging Laboratory, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Via Ardeatina 306, 00179, Rome, Italy.
  • Marzi C; NeuroRadiology, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy.
  • De Luca M; NeuroRadiology, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy.
  • Caltagirone C; Neuropsychology Center, Santa Lucia Foundation IRCCS, Rome, Italy.
  • Santangelo V; Department of Clinical and Behavioral Neurology, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy.
Brain Imaging Behav ; 16(1): 211-218, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34328618
ABSTRACT
A typical consequence of stroke in the right hemisphere is unilateral spatial neglect. Distinct forms of neglect have been described, such as space-based (egocentric) and object-based (allocentric) neglect. However, the relationship between these two forms of neglect is still far from being understood, as well as their neural substrates. Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM) analyses on a large sample of early subacute right-stroke patients assessed with the Apples Cancellation Test. This is a sensitive test that simultaneously measures both egocentric and allocentric neglect. Behaviourally, we found no correlation between egocentric and allocentric performance, indicating independent mechanisms supporting the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a link between a damage in the superior longitudinal fasciculus and left egocentric neglect. By contrast, no association was found between brain damage and left allocentric neglect. These results indicate a higher probability to observe egocentric neglect as a consequence of white matter damages in the superior longitudinal fasciculus, while allocentric neglect appears more "globally" related to the whole lesion map. Overall, these findings on early subacute right-stroke patients highlight the role played by white matter integrity in sustaining attention-related operations within an egocentric frame of reference.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos de la Percepción / Accidente Cerebrovascular / Sustancia Blanca Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos de la Percepción / Accidente Cerebrovascular / Sustancia Blanca Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article