Selective increment of phosphatidylserine on the autophagic body membrane in the yeast vacuole.
FEBS Lett
; 595(17): 2197-2207, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34339521
ABSTRACT
In yeast cells, the autophagosome is a double-membrane structure; the inner membrane becomes the autophagic body membrane in the vacuole. Vacuolar enzymes degrade the autophagic body. There is no critical information regarding its selective degradation. Using the electron microscopy method, distributions of four phospholipids were examined in the autophagosomal and autophagic body membranes upon autophagy induction. The labeling of phosphatidylserine (PtdSer) in the autophagic body membrane dramatically increased after it converted from the autophagosome, but remained low in the vacuolar membrane. PtdSer in the autophagic body membrane also increased in atg15∆ yeast. These results suggest that the selective increment of PtdSer in the autophagic body, but not the vacuolar, membrane, can explain the selective degradation of the autophagic membrane.
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MEDLINE
Asunto principal:
Fosfatidilserinas
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Saccharomyces cerevisiae
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Vacuolas
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Membranas Intracelulares
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Lípidos de la Membrana
Idioma:
En
Año:
2021
Tipo del documento:
Article