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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Kremer, Daniel M; Nelson, Barbara S; Lin, Lin; Yarosz, Emily L; Halbrook, Christopher J; Kerk, Samuel A; Sajjakulnukit, Peter; Myers, Amy; Thurston, Galloway; Hou, Sean W; Carpenter, Eileen S; Andren, Anthony C; Nwosu, Zeribe C; Cusmano, Nicholas; Wisner, Stephanie; Mbah, Nneka E; Shan, Mengrou; Das, Nupur K; Magnuson, Brian; Little, Andrew C; Savani, Milan R; Ramos, Johanna; Gao, Tina; Sastra, Stephen A; Palermo, Carmine F; Badgley, Michael A; Zhang, Li; Asara, John M; McBrayer, Samuel K; di Magliano, Marina Pasca; Crawford, Howard C; Shah, Yatrik M; Olive, Kenneth P; Lyssiotis, Costas A.
Afiliación
  • Kremer DM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Nelson BS; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.
  • Lin L; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
  • Yarosz EL; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Halbrook CJ; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA.
  • Kerk SA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Sajjakulnukit P; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
  • Myers A; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA.
  • Thurston G; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Hou SW; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Carpenter ES; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Andren AC; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
  • Nwosu ZC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Cusmano N; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Wisner S; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Mbah NE; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Shan M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Das NK; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Magnuson B; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Little AC; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Savani MR; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Ramos J; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
  • Gao T; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Sastra SA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Palermo CF; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Badgley MA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
  • Zhang L; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
  • Asara JM; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
  • McBrayer SK; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
  • di Magliano MP; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
  • Crawford HC; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.
  • Shah YM; Department of Pathology, Columbia University Medical Center, New York, NY, USA.
  • Olive KP; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
  • Lyssiotis CA; Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nat Commun ; 12(1): 4860, 2021 08 11.
Article en En | MEDLINE | ID: mdl-34381026
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Aspartato Aminotransferasa Citoplasmática / Ferroptosis Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Aspartato Aminotransferasa Citoplasmática / Ferroptosis Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article