Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 &#945; (PKG1&#945;).

Hanisak, Jennifer; Soriano, Aileen; Adam, Gregory C; Basso, Andrea; Bauman, David; Bell, David; Frank, Emily; O'Donnell, Gregory; Tawa, Paul; Verras, Andreas; Yu, Yang; Zhang, Lei; Seganish, W Michael

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).

Hanisak, Jennifer; Soriano, Aileen; Adam, Gregory C; Basso, Andrea; Bauman, David; Bell, David; Frank, Emily; O'Donnell, Gregory; Tawa, Paul; Verras, Andreas; Yu, Yang; Zhang, Lei; Seganish, W Michael.

Afiliación

Hanisak J; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Soriano A; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Adam GC; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States.
Basso A; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Bauman D; Discovery Biology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Bell D; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Frank E; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
O'Donnell G; Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States.
Tawa P; Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Verras A; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Yu Y; Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
Zhang L; Biologics Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey, 07033 United States.
Seganish WM; Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.

ACS Med Chem Lett ; 12(8): 1275-1282, 2021 Aug 12.

Article en En | MEDLINE | ID: mdl-34413956

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article