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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Anderson, Brooke A; Freestone, Graeme C; Low, Audrey; De-Hoyos, Cheryl L; Iii, William J Drury; Østergaard, Michael E; Migawa, Michael T; Fazio, Michael; Wan, W Brad; Berdeja, Andres; Scandalis, Eli; Burel, Sebastien A; Vickers, Timothy A; Crooke, Stanley T; Swayze, Eric E; Liang, Xuehai; Seth, Punit P.
Afiliación
  • Anderson BA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Freestone GC; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Low A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • De-Hoyos CL; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Iii WJD; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Østergaard ME; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Migawa MT; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Fazio M; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Wan WB; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Berdeja A; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Scandalis E; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Burel SA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Vickers TA; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Crooke ST; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Swayze EE; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Liang X; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
  • Seth PP; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Nucleic Acids Res ; 49(16): 9026-9041, 2021 09 20.
Article en En | MEDLINE | ID: mdl-34417625
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Índice Terapéutico de los Medicamentos Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Índice Terapéutico de los Medicamentos Límite: Animals / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article