Efficacy and safety of magnetic resonance-guided focused ultrasound treatment for refractory chronic pain of medial knee osteoarthritis.
Int J Hyperthermia
; 38(2): 46-55, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34420438
ABSTRACT
OBJECTIVE:
To elucidate the efficacy and safety of MRgFUS in the treatment for refractory pain derived from medial knee OA.METHODS:
Twenty patients with medial knee OA eligible for total knee arthroplasty were included in this prospective, non-controlled study (UMIN000010193). MRgFUS treatment was provided at the site of most severe tenderness around the medial femorotibial joint of each patient under real-time monitoring of temperature. The goal temperature of the targeted bone surface was 55 °C. Numerical rating scale (NRS) worst pain scores, Western Ontario and McMaster Universities osteoarthritis index (WOMAC) scores, EuroQol 5 dimensions index (EQ-5D) scores and pressure pain threshold (PPT) were evaluated before treatment (baseline) and at 1 week and 1, 3, 6, and 12 months post-treatment, respectively. Complications and adverse events were also assessed clinically and radiographically.RESULTS:
Treatment response (a 50% or greater decrease in NRS score) was seen in 14 patients (14/19, 73.7%) at 12 months post-treatment. Mean NRS score rapidly decreased at 1 month after treatment and continued to decline through the following 12 months. At final follow-up, mean NRS score was 3.2 ± 1.9, significantly lower than at baseline (p = 0.0013). Mean WOMAC and EQ-5D scores also improved significantly from 1 month after treatment. Fifteen patients showed significant sustained increases in PPTs at the sites of most severe tenderness. No serious adverse events were observed during and after treatment.CONCLUSIONS:
MRgFUS treatments were effective not only for managing refractory pain, but also for improving physical functions without adverse events in elderly patients with medial knee OA.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dolor Intratable
/
Osteoartritis de la Rodilla
/
Dolor Crónico
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article