Acridine derivatives as inhibitors/poisons of topoisomerase II.
J Appl Toxicol
; 42(4): 544-552, 2022 04.
Article
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| MEDLINE
| ID: mdl-34514603
ABSTRACT
The potential of acridines (amsacrine) as a topoisomerase II inhibitor or poison was first discovered in 1984, and since then, a considerable number of acridine derivatives have been tested as topoisomerase inhibitors/poisons, containing different substituents on the acridine chromophore. This review will discuss a series of studies published over the course of the last decade, which have investigated various novel acridine derivatives against topoisomerase II activity.
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MEDLINE
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Venenos
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Antineoplásicos
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En
Año:
2022
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Article