Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread.

Li, Xiao; Sun, Lu; Zhao, Jing; Tu, Kaihang; Xue, Jia; Guo, Xin; Zhang, Guozhong

Li, Xiao; Sun, Lu; Zhao, Jing; Tu, Kaihang; Xue, Jia; Guo, Xin; Zhang, Guozhong.

Afiliación

Li X; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Sun L; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Zhao J; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Tu K; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Xue J; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Guo X; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.
Zhang G; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural Universitygrid.22935.3f, Beijing, China.

Microbiol Spectr ; 9(2): e0131221, 2021 10 31.

Article en En | MEDLINE | ID: mdl-34585949

Asunto(s)

Secuencias de Aminoácidos/genética; Metiltransferasas/genética; Enfermedad de Newcastle/transmisión; Virus de la Enfermedad de Newcastle/crecimiento & desarrollo; Virus de la Enfermedad de Newcastle/genética; Proteínas Virales/genética; Animales; Línea Celular; Pollos; Chlorocebus aethiops; Cricetinae; Genoma Viral/genética; Virus de la Enfermedad de Newcastle/patogenicidad; Enfermedades de las Aves de Corral/transmisión; Enfermedades de las Aves de Corral/virología; ARN Viral/biosíntesis; ARN Viral/genética; Células Vero; Virulencia/genética; Replicación Viral/genética

Palabras clave

K-D-K-E motif; Newcastle disease virus; cell-to-cell spread; large polymerase protein; negative-stranded RNA virus; viral translation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Virales / Virus de la Enfermedad de Newcastle / Secuencias de Aminoácidos / Metiltransferasas / Enfermedad de Newcastle Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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