Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group.
J Parkinsons Dis
; 12(1): 315-331, 2022.
Article
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| MEDLINE
| ID: mdl-34602501
ABSTRACT
BACKGROUND:
Constipation has been linked to cognitive impairment development in Parkinson's disease (PD).OBJECTIVE:
Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation.METHODS:
PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson's Disease Cognitive Rating Scale). Subjects with a score ≥1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as "with constipation". Regression analyses were applied for determining the contribution of constipation in cognitive changes.RESULTS:
At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (pâ<â0.0001). No change was observed in cognitive status (PD-CRS total score) neither in controls without constipation (from 100.24±13.72 to 100.27±13.68; pâ=â0.971) and with constipation (from 94.71±10.96 to 93.93±13.03; pâ=â0.615). The PD-CRS total score decreased significantly in PD patients with constipation (from 89.14±15.36 to 85.97±18.09; pâ<â0.0001; Coehn's effectâ=â-0.35) compared to patients without constipation (from 93.92±15.58 to 93.14±17.52; pâ=â0.250) (pâ=â0.018). In PD patients, to suffer from constipation at V0 was associated with a decrease in the PD-CRS total score from V0 to V2 (ß=â-0.1; 95% CI, -4.36 - -0.27; pâ=â0.026) and having cognitive impairment at V2 (ORâ=â1.79; 95% CI, 1.01 - 3.17; pâ=â0.045).CONCLUSION:
Constipation is associated with cognitive decline in PD patients but not in controls.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Disfunción Cognitiva
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article