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Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Lee, Kun-Hung; Yen, Wan-Ching; Lin, Wen-Hsing; Wang, Pei-Chen; Lai, You-Liang; Su, Yu-Chieh; Chang, Chun-Yu; Wu, Cai-Syuan; Huang, Yu-Chen; Yang, Chen-Ming; Chou, Ling-Hui; Yeh, Teng-Kuang; Chen, Chiung-Tong; Shih, Chuan; Hsieh, Hsing-Pang.
Afiliación
  • Lee KH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Yen WC; Department of Chemistry, National Tsing Hua University, Hsinchu City 300, Taiwan, ROC.
  • Lin WH; Biomedical Translation Research Center, Academia Sinica, Taipei City 115, Taiwan, ROC.
  • Wang PC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Lai YL; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Su YC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Chang CY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Wu CS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Huang YC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Yang CM; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Chou LH; Department of Chemistry, National Tsing Hua University, Hsinchu City 300, Taiwan, ROC.
  • Yeh TK; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Chen CT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Shih C; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
  • Hsieh HP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
J Med Chem ; 64(19): 14477-14497, 2021 10 14.
Article en En | MEDLINE | ID: mdl-34606263
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor de Factor Estimulante de Colonias de Macrófagos / Neoplasias del Colon / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Agentes Inmunomoduladores / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor de Factor Estimulante de Colonias de Macrófagos / Neoplasias del Colon / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Agentes Inmunomoduladores / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article