Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program.

Wei, Yiju; Luo, Huacheng; Yee, Patricia P; Zhang, Lijun; Liu, Zhijun; Zheng, Haiyan; Zhang, Lei; Anderson, Benjamin; Tang, Miaolu; Huang, Suming; Li, Wei

Wei, Yiju; Luo, Huacheng; Yee, Patricia P; Zhang, Lijun; Liu, Zhijun; Zheng, Haiyan; Zhang, Lei; Anderson, Benjamin; Tang, Miaolu; Huang, Suming; Li, Wei.

Afiliación

Wei Y; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Luo H; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Yee PP; Department of Pharmacology, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Zhang L; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Liu Z; Institute for Personalized Medicine, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Zheng H; Department of Biochemistry & Molecular Biology, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Zhang L; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Anderson B; Biological Mass Spectrometry Facility, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Tang M; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.
Huang S; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
Li W; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Penn State Health Hershey Medical Center, Penn State College of Medicine, Hershey, PA, 17033, USA.

Adv Sci (Weinh) ; 8(24): e2102653, 2021 12.

Article en En | MEDLINE | ID: mdl-34716691

Asunto(s)

Neoplasias Encefálicas/metabolismo; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Glioblastoma/metabolismo; Vía de Señalización Hippo/genética; Oncogenes/genética; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Activación Transcripcional/genética; Animales; Neoplasias Encefálicas/genética; Línea Celular Tumoral; Modelos Animales de Enfermedad; Femenino; Glioblastoma/genética; Humanos; Ratones; Ratones Desnudos; Transducción de Señal/genética; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

Hippo pathway; NONO; TAZ; glioblastoma; liquid-liquid phase separation; transcription regulation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oncogenes / Neoplasias Encefálicas / Activación Transcripcional / Proteínas de Unión al ARN / Glioblastoma / Proteínas de Unión al ADN / Vía de Señalización Hippo Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article

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