Kinetics of dopamine oxidation by dialkylaminoalkylphenothiazine cation radicals.

ABSTRACT

The kinetics of dopamine oxidatinon dialkylaminoalkylphenothiazine cation radicals (with two- or three-carbon side chains) were investigated. The two-carbon side-chain derivatives have reaction rates higher than the three-carbon ones. For chlorpromazine and promazine, extrapolation of pH 1-6 data shows that reaction rates become very fast at physiological pH.