Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.
Proc Natl Acad Sci U S A
; 118(47)2021 11 23.
Article
en En
| MEDLINE
| ID: mdl-34782459
ABSTRACT
Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States-African American or United States-European American AIDS cohorts or in both. Each associated gene has a prior reported influence on HIV/AIDS pathogenesis. Thirteen previously discovered AIDS restriction genes were further replicated in the Botswana cohorts, extending our confidence in these prior AIDS restriction gene reports. This work presents an early step toward the identification of genetic variants associated with and affecting HIV acquisition or AIDS progression in the understudied HIV-1C afflicted Botswana population.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Infecciones por VIH
/
Estudio de Asociación del Genoma Completo
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Año:
2021
Tipo del documento:
Article