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Severe COVID-19 is associated with hyperactivation of the alternative complement pathway.
Boussier, Jeremy; Yatim, Nader; Marchal, Armance; Hadjadj, Jérôme; Charbit, Bruno; El Sissy, Carine; Carlier, Nicolas; Pène, Frédéric; Mouthon, Luc; Tharaux, Pierre-Louis; Bergeron, Anne; Smadja, David M; Rieux-Laucat, Frédéric; Duffy, Darragh; Kernéis, Solen; Frémeaux-Bacchi, Véronique; Terrier, Benjamin.
Afiliación
  • Boussier J; Sorbonne Université, AP-HP Hôpital Saint-Antoine, Paris, France.
  • Yatim N; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP Hôpital Cochin, Paris, France; Translational Immunology Lab, Department of Immunology, Institut Pasteur, Paris, France.
  • Marchal A; Laboratory of Immunology, AP-HP Hôpital Européen Georges Pompidou, Paris, France.
  • Hadjadj J; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP Hôpital Cochin, Paris, France; Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Institut national de la santé et de la recherche médicale (Inserm) U1163, Institu
  • Charbit B; Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Paris, France.
  • El Sissy C; Laboratory of Immunology, AP-HP Hôpital Européen Georges Pompidou, Paris, France.
  • Carlier N; Department of Pulmonology, AP-HP Hôpital Cochin, Paris, France.
  • Pène F; Université de Paris, Institut Cochin, Inserm U1016, CNRS UMR 8104, Paris, France; Service de Médecine Intensive et Réanimation, AP-HP Hôpital Cochin, Paris, France.
  • Mouthon L; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP Hôpital Cochin, Paris, France; Service de Médecine Intensive et Réanimation, AP-HP Hôpital Cochin, Paris, France.
  • Tharaux PL; Université de Paris, Paris Cardiovascular Center (PARCC), Inserm, Paris, France.
  • Bergeron A; Université de Paris, UMR 1153 Centre of Research in Epidemiology and Statistics (CRESS), Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation Assessments Team, Service de Pneumologie, Hôpital Saint Louis, Paris, France.
  • Smadja DM; Université de Paris, Innovative Therapies in Hemostasis, Inserm, Paris, France; Hematology Department, AP-HP Hôpital Cochin, Paris, France; Biosurgical Research Lab (Carpentier Foundation), AP-HP Hôpital Européen Georges Pompidou, Paris, France.
  • Rieux-Laucat F; Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Institut national de la santé et de la recherche médicale (Inserm) U1163, Institut Imagine, Paris, France.
  • Duffy D; Translational Immunology Lab, Department of Immunology, Institut Pasteur, Paris, France; Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Paris, France.
  • Kernéis S; Équipe de Prévention du Risque Infectieux, AP-HP Hôpital Bichat, Paris, France; Université de Paris, Inserm, IAME, Paris, France.
  • Frémeaux-Bacchi V; Laboratory of Immunology, AP-HP Hôpital Européen Georges Pompidou, Paris, France.
  • Terrier B; Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP Hôpital Cochin, Paris, France; Université de Paris, Paris Cardiovascular Center (PARCC), Inserm, Paris, France. Electronic address: benjamin.terrier@aphp.fr.
J Allergy Clin Immunol ; 149(2): 550-556.e2, 2022 02.
Article en En | MEDLINE | ID: mdl-34800432
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas del Sistema Complemento / Activación de Complemento / Vía Alternativa del Complemento / Coagulación Intravascular Diseminada / SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas del Sistema Complemento / Activación de Complemento / Vía Alternativa del Complemento / Coagulación Intravascular Diseminada / SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2022 Tipo del documento: Article