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Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
Kolos, Jürgen M; Pomplun, Sebastian; Jung, Sascha; Rieß, Benedikt; Purder, Patrick L; Voll, Andreas M; Merz, Stephanie; Gnatzy, Monika; Geiger, Thomas M; Quist-Løkken, Ingrid; Jatzlau, Jerome; Knaus, Petra; Holien, Toril; Bracher, Andreas; Meyners, Christian; Czodrowski, Paul; Krewald, Vera; Hausch, Felix.
Afiliación
  • Kolos JM; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Pomplun S; Max Planck Institute of Psychiatry Kraepelinstr. 2-10 80804 München Germany.
  • Jung S; Max Planck Institute of Psychiatry Kraepelinstr. 2-10 80804 München Germany.
  • Rieß B; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie Otto-Hahn-Straße 6 44227 Dortmund Germany.
  • Purder PL; Max Planck Institute of Psychiatry Kraepelinstr. 2-10 80804 München Germany.
  • Voll AM; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Merz S; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Gnatzy M; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Geiger TM; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Quist-Løkken I; Department of Chemistry, Technical University of Darmstadt Alarich-Weiss-Straße 4 64293 Darmstadt Germany felix.hausch@tu-darmstadt.de.
  • Jatzlau J; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology 7491 Trondheim Norway.
  • Knaus P; Department of Immunology and Transfusion Medicine, St. Olav's University Hospital 7030 Trondheim Norway.
  • Holien T; Department of Hematology, St. Olav's University Hospital 7030 Trondheim Norway.
  • Bracher A; Institute for Chemistry and Biochemistry, Freie Universität Berlin 14195 Berlin Germany.
  • Meyners C; Institute for Chemistry and Biochemistry, Freie Universität Berlin 14195 Berlin Germany.
  • Czodrowski P; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology 7491 Trondheim Norway.
  • Krewald V; Department of Immunology and Transfusion Medicine, St. Olav's University Hospital 7030 Trondheim Norway.
  • Hausch F; Department of Hematology, St. Olav's University Hospital 7030 Trondheim Norway.
Chem Sci ; 12(44): 14758-14765, 2021 Nov 17.
Article en En | MEDLINE | ID: mdl-34820091
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article