A Study on Synthesis and Upscaling of 2'-<i>O</i>-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis.

Karale, Kristina; Bollmark, Martin; Stulz, Rouven; Honcharenko, Dmytro; Tedebark, Ulf; Strömberg, Roger

A Study on Synthesis and Upscaling of 2'-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis.

Karale, Kristina; Bollmark, Martin; Stulz, Rouven; Honcharenko, Dmytro; Tedebark, Ulf; Strömberg, Roger.

Afiliación

Karale K; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.
Bollmark M; RISE, Department Chemical Process and Pharmaceutical Development, Forskargatan 18, 151 36 Södertälje, Sweden.
Stulz R; RISE, Department Chemical Process and Pharmaceutical Development, Forskargatan 18, 151 36 Södertälje, Sweden.
Honcharenko D; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.
Tedebark U; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, 431 50 Gothenburg, Sweden.
Strömberg R; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 57 Huddinge, Sweden.

Molecules ; 26(22)2021 Nov 17.

Article en En | MEDLINE | ID: mdl-34834019

Asunto(s)

Citidina/análogos & derivados; Oligonucleótidos/química; Oligonucleótidos/síntesis química; Compuestos Organofosforados/química; Uridina/análogos & derivados; Citidina/química; Uridina/química

Palabras clave

2'-O-(N-(aminoethyl)carbamoyl)methyl modification; 5-methylcytidine; 5-methyluridine; alkylation; monoacetylation; oligonucleotides; phase transfer catalysis (PTC)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligonucleótidos / Compuestos Organofosforados / Uridina / Citidina Idioma: En Año: 2021 Tipo del documento: Article

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