Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.
Int J Mol Sci
; 22(23)2021 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-34884813
ABSTRACT
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, "multi-omics" immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Citocinas
/
Sepsis
/
Síndrome de Liberación de Citoquinas
/
COVID-19
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article