Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection risk.

Chen, Ping; Wang, Jingfang; Xu, Xintian; Li, Yuping; Zhu, Yan; Li, Xuan; Li, Ming; Hao, Pei

Chen, Ping; Wang, Jingfang; Xu, Xintian; Li, Yuping; Zhu, Yan; Li, Xuan; Li, Ming; Hao, Pei.

Afiliación

Chen P; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China; Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Wang J; Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Xu X; Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100039, China.
Li Y; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Zhu Y; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai 200032, China.
Li X; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Science, Chinese Academy of Sciences, Shanghai 200032, China; University of Chinese Academy of Sciences, Beijing 100039, China. Electronic address: lixuan@sippe.ac.cn.
Li M; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Electronic address: lm_nutr@scu.edu.cn.
Hao P; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China; Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100039, China. Electronic address: phao@ips.ac.cn.

Comput Biol Chem ; 96: 107613, 2022 Feb.

Article en En | MEDLINE | ID: mdl-34896769

Asunto(s)

Enzima Convertidora de Angiotensina 2/química; COVID-19/veterinaria; COVID-19/virología; Mutación Missense; SARS-CoV-2/química; SARS-CoV-2/genética; Glicoproteína de la Espiga del Coronavirus/química; Glicoproteína de la Espiga del Coronavirus/genética; Enzima Convertidora de Angiotensina 2/genética; Animales; Animales Salvajes/genética; Animales Salvajes/virología; COVID-19/transmisión; Biología Computacional; Interacciones Microbiota-Huesped/genética; Especificidad del Huésped/genética; Humanos; Simulación de Dinámica Molecular; Pandemias/veterinaria; Peptidil-Dipeptidasa A/química; Peptidil-Dipeptidasa A/genética; Mascotas/genética; Mascotas/virología; Dominios y Motivos de Interacción de Proteínas/genética; Factores de Riesgo

Palabras clave

ACE2 receptor recognition; Animal host; Molecular dynamics simulations; Molecular modeling; Mutations; SARS-CoV-2 spike protein

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Mutación Missense / Glicoproteína de la Espiga del Coronavirus / Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / COVID-19 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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