Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.

Bloom, A Joseph; Mao, Xianrong; Strickland, Amy; Sasaki, Yo; Milbrandt, Jeffrey; DiAntonio, Aaron

Bloom, A Joseph; Mao, Xianrong; Strickland, Amy; Sasaki, Yo; Milbrandt, Jeffrey; DiAntonio, Aaron.

Afiliación

Bloom AJ; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA. ajbloom@wustl.edu.
Mao X; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
Strickland A; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
Sasaki Y; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
Milbrandt J; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA. jmilbrandt@wustl.edu.
DiAntonio A; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Developmental Biology, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA. diantonio@wustl.edu.

Mol Neurodegener ; 17(1): 1, 2022 01 06.

Article en En | MEDLINE | ID: mdl-34991663

Asunto(s)

Esclerosis Amiotrófica Lateral; Proteínas del Dominio Armadillo; Proteínas del Citoesqueleto; Enfermedades Neurodegenerativas; Esclerosis Amiotrófica Lateral/genética; Esclerosis Amiotrófica Lateral/metabolismo; Animales; Proteínas del Dominio Armadillo/química; Proteínas del Dominio Armadillo/genética; Proteínas del Dominio Armadillo/metabolismo; Axones/metabolismo; Proteínas del Citoesqueleto/genética; Proteínas del Citoesqueleto/metabolismo; Humanos; Ratones; Enfermedades Neurodegenerativas/metabolismo

Palabras clave

ALS; Axon; Human genetics; NAD; Neurodegeneration; Neuropathy; SARM1

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas del Citoesqueleto / Proteínas del Dominio Armadillo / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google