Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays.

Curreli, Francesca; Ahmed, Shahad; Victor, Sofia M B; Drelich, Aleksandra; Panda, Siva S; Altieri, Andrea; Kurkin, Alexander V; Tseng, Chien-Te K; Hillyer, Christopher D; Debnath, Asim K

Curreli, Francesca; Ahmed, Shahad; Victor, Sofia M B; Drelich, Aleksandra; Panda, Siva S; Altieri, Andrea; Kurkin, Alexander V; Tseng, Chien-Te K; Hillyer, Christopher D; Debnath, Asim K.

Afiliación

Curreli F; Laboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Ahmed S; Laboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Victor SMB; Laboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Drelich A; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Panda SS; Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
Altieri A; EDASA Scientific, Scientific Campus, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Kurkin AV; EDASA Scientific, Scientific Campus, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Tseng CK; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Hillyer CD; Center of Biodefense and Emerging Disease, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Debnath AK; New York Blood Center, New York, NY 10065, USA.

Viruses ; 14(1)2021 12 31.

Article en En | MEDLINE | ID: mdl-35062273

Asunto(s)

Antivirales/farmacología; SARS-CoV-2/efectos de los fármacos; Internalización del Virus/efectos de los fármacos; Animales; Antivirales/química; Antivirales/farmacocinética; Disponibilidad Biológica; Línea Celular; Supervivencia Celular/efectos de los fármacos; Coronavirus/clasificación; Coronavirus/efectos de los fármacos; Inhibidores de Fusión de VIH/química; Inhibidores de Fusión de VIH/farmacocinética; Inhibidores de Fusión de VIH/farmacología; Humanos; Unión Proteica; Ratas; Bibliotecas de Moléculas Pequeñas/química; Bibliotecas de Moléculas Pequeñas/farmacocinética; Bibliotecas de Moléculas Pequeñas/farmacología; Glicoproteína de la Espiga del Coronavirus/antagonistas & inhibidores

Palabras clave

COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; fusion inhibitor; middle east respiratory syndrome (MERS); pan-coronavirus; severe acute respiratory syndrome (SARS)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Internalización del Virus / SARS-CoV-2 Límite: Animals / Humans Idioma: En Año: 2021 Tipo del documento: Article

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