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Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription.
Wang, Dongfang; Tan, Keai Sinn; Zeng, Weiping; Li, Sixu; Wang, Yueqi; Xu, Fapeng; Tan, Wen.
Afiliación
  • Wang D; School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China; Post-Doctoral Innovation Base, Jinan University Affiliation, Yuanzhi Health Technology Co, Ltd, Hengqin New District, Zhuhai, Guangdong 51900, China. Electronic address: dfwang@jnu.edu.cn.
  • Tan KS; School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China; Post-Doctoral Innovation Base, Jinan University Affiliation, Yuanzhi Health Technology Co, Ltd, Hengqin New District, Zhuhai, Guangdong 51900, China.
  • Zeng W; School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China.
  • Li S; Post-Doctoral Innovation Base, Jinan University Affiliation, Yuanzhi Health Technology Co, Ltd, Hengqin New District, Zhuhai, Guangdong 51900, China.
  • Wang Y; School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China.
  • Xu F; School of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China.
  • Tan W; Post-Doctoral Innovation Base, Jinan University Affiliation, Yuanzhi Health Technology Co, Ltd, Hengqin New District, Zhuhai, Guangdong 51900, China; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.
Life Sci ; 293: 120336, 2022 Mar 15.
Article en En | MEDLINE | ID: mdl-35065166
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Transcripción Genética / Butirilcolinesterasa / Receptores de LDL / Hepatocitos / Hipercolesterolemia Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Transcripción Genética / Butirilcolinesterasa / Receptores de LDL / Hepatocitos / Hipercolesterolemia Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2022 Tipo del documento: Article