Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Org Process Res Dev
; 25(12): 2806-2815, 2021 Dec 17.
Article
en En
| MEDLINE
| ID: mdl-35095257
ABSTRACT
Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process.
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MEDLINE
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2021
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Article