Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals.
Future Microbiol
; 17: 281-291, 2022 03.
Article
en En
| MEDLINE
| ID: mdl-35152707
Plain language summary Drugs for the treatment of fungal diseases are limited in number and present side effects, drug interactions, risks for pregnant women and fungal resistance. The authors produced a derivative compound from plants called octyl gallate (OG) and then incorporated it into a nanoparticle lipid system (NLS) for better distribution in biological fluids. NLS-OG was tested against a fungus called Paracoccidioides, which causes lung infections. The toxicity profile of NLS-OG was also evaluated in lung and hepatic cells as well as novel animal models. NLS-OG presented good antifungal activity and low toxicity in lung cells and embryos.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Paracoccidioides
/
Antifúngicos
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article