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SnapShot: Regulation and biology of PGC-1α.
Jannig, Paulo R; Dumesic, Phillip A; Spiegelman, Bruce M; Ruas, Jorge L.
Afiliación
  • Jannig PR; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 17165 Stockholm, Sweden.
  • Dumesic PA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Spiegelman BM; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Ruas JL; Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 17165 Stockholm, Sweden.
Cell ; 185(8): 1444-1444.e1, 2022 04 14.
Article en En | MEDLINE | ID: mdl-35427500
ABSTRACT
The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes. Expressing specific PGC-1α isoforms in mice can confer protection in different disease models. This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein stability, and activity underlies its multifaceted functions. To view this SnapShot, open or download the PDF.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Mitocondrias Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Mitocondrias Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article