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Cytotoxic and antimicrobial drimane meroterpenoids from a fungus of the Stictidaceae (Ostropales, Ascomycota).
Flores-Bocanegra, Laura; Augustinovic, Mario; Raja, Huzefa A; Kurina, Steven J; Maldonado, Amanda C; Burdette, Joanna E; Falkinham, Joseph O; Pearce, Cedric J; Oberlies, Nicholas H.
Afiliación
  • Flores-Bocanegra L; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Augustinovic M; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Raja HA; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
  • Kurina SJ; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Maldonado AC; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Burdette JE; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Falkinham JO; Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
  • Pearce CJ; Mycosynthetix, Inc., Hillsborough, North Carolina 27278, United States.
  • Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Tetrahedron Lett ; 682021 Mar 30.
Article en En | MEDLINE | ID: mdl-35431352
ABSTRACT
As part of our ongoing research on bioactive fungal metabolites, two new metabolites were isolated from a fungus of the Stictidaceae (strain MSX62440), dasyscyphins F and G (1 and 3), and the known dasyscyphin C (2). Compound 1 was characterized by HRMS and 1D and 2D NMR data, and its absolute configuration established by ECD spectroscopy. A structural revision of dasyscyphin C (2) was based on NMR data and verified by ECD calculations. Compound 3 was reported previously as a synthetic product, and its identity confirmed by comparison with NMR data in the literature, and its absolute configuration was established by ECD spectroscopy. Compounds 1 and 2 showed moderate cytotoxicity and antimicrobial activity.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2021 Tipo del documento: Article