Your browser doesn't support javascript.
loading
Prognostic Value of Systemic Inflammatory Response Markers in Patients Undergoing Neoadjuvant Chemotherapy and Gastrectomy for Advanced Gastric Cancer in the Eastern European Population.
Pikula, Agnieszka; Skórzewska, Magdalena; Pelc, Zuzanna; Mlak, Radoslaw; Geca, Katarzyna; Sedlak, Katarzyna; Cisel, Bogumila; Kwietniewska, Magdalena; Rawicz-Pruszynski, Karol; Polkowski, Wojciech P.
Afiliación
  • Pikula A; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Skórzewska M; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Pelc Z; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Mlak R; Department of Human Physiology, Medical University of Lublin, Radziwillowska 11 St., 20-080 Lublin, Poland.
  • Geca K; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Sedlak K; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Cisel B; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Kwietniewska M; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Rawicz-Pruszynski K; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
  • Polkowski WP; Department of Surgical Oncology, Medical University of Lublin, Radziwillowska 13 St., 20-080 Lublin, Poland.
Cancers (Basel) ; 14(8)2022 Apr 14.
Article en En | MEDLINE | ID: mdl-35454903
ABSTRACT
The prognostic value of the systemic inflammatory response markers, namely neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) has not yet been clarified in patients undergoing neoadjuvant chemotherapy (NAC) and gastrectomy for advanced gastric cancer (GC) in the Eastern European population. This study aimed to verify the prognostic value of NLR, PLR, and LMR in GC patients undergoing multimodal treatment. One hundred six GC patients undergoing NAC and gastrectomy between 2012 and 2020 were included. Analysed blood samples were obtained prior to NAC (pre-NAC group) and before surgical treatment (post-NAC group). To evaluate the prognostic value of the NLR, LMR, and PLR, univariable and multivariable overall survival (OS) analyses were performed. In the pre-NAC group, elevated NLR and PLR were associated with significantly higher risk of death (mOS 36 vs. 87 months; HR = 2.21; p = 0.0255 and mOS 30 vs. 87 months; HR = 2.89; p = 0.0034, respectively). Additionally, a significantly higher risk of death was observed in patients with elevated NLR in the post-NAC group (mOS 35 vs. 87 months; HR = 1.94; p = 0.0368). Selected systemic inflammatory response markers (NLR, PLR) are significant prognostic factors in patients with advanced GC treated with NAC and gastrectomy, as shown in the Eastern European population.
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article