The recombinant defensin/HSA fusion protein that inhibits NF-&#954;b associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer.

Du, Yi-Bo; Wang, Xiao-Fei; Liu, Xiu-Jun; Li, Yi; Miao, Qing-Fang; Jiang, Min; Sheng, Wei-Jin; Zhen, Yong-Su

The recombinant defensin/HSA fusion protein that inhibits NF-κb associated with intensive macropinocytosis shows potent efficacy against pancreatic cancer.

Du, Yi-Bo; Wang, Xiao-Fei; Liu, Xiu-Jun; Li, Yi; Miao, Qing-Fang; Jiang, Min; Sheng, Wei-Jin; Zhen, Yong-Su.

Afiliación

Du YB; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang XF; Lepu Biopharma Co., Ltd., Beijing 101204, China.
Liu XJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Li Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Miao QF; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Jiang M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Sheng WJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: swj_zjnb@imb.cams.cn.
Zhen YS; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: zhenys@imb.pumc.edu.cn.

Biochem Pharmacol ; 201: 115057, 2022 07.

Article en En | MEDLINE | ID: mdl-35489393

Asunto(s)

FN-kappa B; Neoplasias Pancreáticas; Animales; Apoptosis; Línea Celular Tumoral; Proliferación Celular; Humanos; Ratones; FN-kappa B/metabolismo; Neoplasias Pancreáticas/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Proteínas Recombinantes de Fusión/metabolismo; Proteínas Recombinantes/metabolismo; Proteínas Recombinantes/farmacología; Albúmina Sérica Humana/metabolismo; Albúmina Sérica Humana/farmacología; Ensayos Antitumor por Modelo de Xenoinjerto; Neoplasias Pancreáticas

Palabras clave

KRAS; Macropinocytosis; NF-κB; Pancreatic cancer; Recombinant fusion protein

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / FN-kappa B Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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