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Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
Rogers, Maximillian A; Chang, Catherine C Y; Maue, Robert A; Melton, Elaina M; Peden, Andrew A; Garver, William S; Lee, Junghoon; Schroen, Peter; Huang, Mitchell; Chang, Ta-Yuan.
Afiliación
  • Rogers MA; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Chang CCY; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Maue RA; Department of Biology, Dartmouth College, Hanover, NH 03755.
  • Melton EM; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Peden AA; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Sheffield S10 2TN, United Kingdom.
  • Garver WS; Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, NM 87131.
  • Lee J; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Schroen P; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Huang M; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
  • Chang TY; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Proc Natl Acad Sci U S A ; 119(18): e2201646119, 2022 05 03.
Article en En | MEDLINE | ID: mdl-35507892
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Niemann-Pick Tipo C / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Niemann-Pick Tipo C / Longevidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article