Exosome is involved in liver graft protection after remote ischemia reperfusion conditioning.
Hepatobiliary Pancreat Dis Int
; 22(5): 498-503, 2023 Oct.
Article
en En
| MEDLINE
| ID: mdl-35534341
ABSTRACT
BACKGROUND:
Remote ischemic perconditioning (RIPerC) has been demonstrated to protect grafts from hepatic ischemia-reperfusion injury (IRI). This study investigated the role of exosomes in RIPerC of liver grafts in rats.METHODS:
Twenty-five rats (including 10 donors) were randomly divided into five groups (n = 5 each group) five rats were used as sham-operated controls (Sham), ten rats were for orthotopic liver transplantation (OLT, 5 donors and 5 recipients) and ten rats were for OLT + RIPerC (5 donors and 5 recipients). Liver architecture and function were evaluated.RESULTS:
Compared to the OLT group, the OLT + RIPerC group exhibited significantly improved liver graft histopathology and liver function (P < 0.05). Furthermore, the number of exosomes and the level of P-Akt were increased in the OLT + RIPerC group.CONCLUSIONS:
RIPerC effectively improves graft architecture and function, and this protective effect may be related to the increased number of exosomes. The upregulation of P-Akt may be involved in underlying mechanisms.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Trasplante de Hígado
/
Exosomas
Límite:
Animals
Idioma:
En
Año:
2023
Tipo del documento:
Article