Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66.
Food Chem
; 391: 133238, 2022 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-35598392
ABSTRACT
The purpose of this study was to treat UiO-66 (University of Oslo 66) under suitable thermal alkaline hydrolysis condition to realize the loading of gallic acid. UiO-66-SH (UiO-66-separated-heating) was obtained by separated heating UiO-66 and 0.2 M KOH aqueous solution to 120 â before mixing for 3 h. The material was in an amorphous state, maintained the octahedron structure and size of UiO-66. UiO-66-SH has better porosity and specific surface area than UiO-66, and had good thermal stability until heated to 1000 â. Furthermore, UiO-66-SH had very little influence of the cellular activity of human normal heptical cell line, demonstrating its good biocompatibility. The prepared UiO-66-SH could successfully adsorb gallic acid and control the release of gallic acid in simulated gastric fluid (â¼58% vs. â¼ 88% of free gallic acid). This study will be conducive to preparation of appropriate carrier used to load with polyphenolic compounds such as gallic acid.
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Banco de datos:
MEDLINE
Asunto principal:
Estructuras Metalorgánicas
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Humans
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En
Año:
2022
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Article