A DNA damage nanoamplifier for the chemotherapy of triple-negative breast cancer via DNA damage induction and repair blocking.

Huang, Yanjuan; Dai, Xiuling; Guan, Zilin; Liu, Di; Ren, Lingling; Chen, Meixu; Zeng, Zishan; Jiang, Jingwen; Luo, Yong; He, Yuanfeng; Huang, Min; Zhao, Chunshun

Huang, Yanjuan; Dai, Xiuling; Guan, Zilin; Liu, Di; Ren, Lingling; Chen, Meixu; Zeng, Zishan; Jiang, Jingwen; Luo, Yong; He, Yuanfeng; Huang, Min; Zhao, Chunshun.

Afiliación

Huang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Dai X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Guan Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Liu D; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Ren L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Chen M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zeng Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Jiang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Luo Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
He Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Huang M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhao C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: zhaocs@mail.sysu.edu.cn.

Int J Pharm ; 622: 121897, 2022 Jun 25.

Article en En | MEDLINE | ID: mdl-35690308

Asunto(s)

Neoplasias de la Mama Triple Negativas; Línea Celular Tumoral; Daño del ADN; Humanos; Inhibidores de Poli(ADP-Ribosa) Polimerasas/farmacología; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Poli(ADP-Ribosa) Polimerasas; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Neoplasias de la Mama Triple Negativas/genética; Neoplasias de la Mama Triple Negativas/patología

Palabras clave

DNA damage repair; Liposome; Niraparib; PARP inhibitor; Platinum(IV) prodrug; Triple-negative breast cancer

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Triple Negativas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article