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Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats.
Illes-Toth, Eva; Hale, Oliver J; Hughes, James W; Strittmatter, Nicole; Rose, Jonathan; Clayton, Ben; Sargeant, Rebecca; Jones, Stewart; Dannhorn, Andreas; Goodwin, Richard J A; Cooper, Helen J.
Afiliación
  • Illes-Toth E; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Hale OJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Hughes JW; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Strittmatter N; Imaging & Data Analytics, Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Rose J; Animal Sciences & Technologies, Clinical Pharmacology & Safety Sciences, AstraZeneca, Babraham Research Campus, Babraham, Cambridge, CB22 3AT, UK.
  • Clayton B; Animal Sciences & Technologies, Clinical Pharmacology & Safety Sciences, AstraZeneca, Babraham Research Campus, Babraham, Cambridge, CB22 3AT, UK.
  • Sargeant R; Imaging & Data Analytics, Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Jones S; Imaging & Data Analytics, Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Dannhorn A; Imaging & Data Analytics, Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Goodwin RJA; Imaging & Data Analytics, Clinical Pharmacology & Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Cooper HJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Angew Chem Int Ed Engl ; 61(36): e202202075, 2022 09 05.
Article en En | MEDLINE | ID: mdl-35830332
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bezafibrato / Hígado Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bezafibrato / Hígado Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article