Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas.
Cancers (Basel)
; 14(14)2022 Jul 12.
Article
en En
| MEDLINE
| ID: mdl-35884442
ABSTRACT
Intratumor heterogeneity (ITH) is a constant evolutionary event in all malignant tumors, and clear cell renal cell carcinoma (CCRCC) is a paradigmatic example. ITH is responsible for most therapeutic failures in the era of precision oncology, so its precise detection remains a must in modern medicine. Unfortunately, classic sampling protocols do not resolve the problem as expected and several strategies have been being implemented in recent years to improve such detection. Basically, multisite tumor sampling (MSTS) and the homogenization of the residual tumor tissue are on display. A next step of the MSTS strategy considering the recently discovered patterns of ITH regionalization is presented here, the so-called personalized MSTS (pMSTS). This modification consists of paying more attention to sample the tumor periphery since it is this area with maximum levels of ITH.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Guideline
Idioma:
En
Año:
2022
Tipo del documento:
Article