Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach.

Chen, Chang; Qian, Jiahui; Zhao, Xinyu; Han, Xuyang; Tang, Xu; Gao, Junfeng; Liu, Yan; Jiang, Jinzhu; Wen, Binyu

Chen, Chang; Qian, Jiahui; Zhao, Xinyu; Han, Xuyang; Tang, Xu; Gao, Junfeng; Liu, Yan; Jiang, Jinzhu; Wen, Binyu.

Afiliación

Chen C; Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P. R. China.
Qian J; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China.
Zhao X; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China.
Han X; Beijing Institute of Traditional Chinese Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, P. R. China.
Tang X; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China.
Gao J; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China.
Liu Y; Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P. R. China.
Jiang J; Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P. R. China.
Wen B; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, P. R. China.

Biomed Chromatogr ; 36(11): e5469, 2022 Nov.

Article en En | MEDLINE | ID: mdl-35904380

Asunto(s)

Enfermedad Hepática Inducida por Sustancias y Drogas; Emodina; Hígado Graso; Miembro 11 de la Subfamilia B de Transportador de Casetes de Unión al ATP; Animales; Aspartato Aminotransferasas; Ácidos y Sales Biliares/metabolismo; Bilirrubina/metabolismo; Bilirrubina/farmacología; Biomarcadores/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Colesterol; Cromatografía Liquida; Emodina/metabolismo; Hígado Graso/metabolismo; Hígado Graso/patología; Glicerofosfolípidos/metabolismo; Hígado/metabolismo; Espectrometría de Masas; ARN Mensajero/metabolismo; ARN Mensajero/farmacología; Ratas; Silibina/metabolismo; Silibina/farmacología; Vitaminas/metabolismo; Vitaminas/farmacología

Palabras clave

Bsep; Cyp7a1; drug-induced liver injury; metabolomics; silybin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Emodina / Hígado Graso / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

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