Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the ß-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup.

Orlowska, Karina; Fling, Russ R; Nault, Rance; Sink, Warren J; Schilmiller, Anthony L; Zacharewski, Tim

Orlowska, Karina; Fling, Russ R; Nault, Rance; Sink, Warren J; Schilmiller, Anthony L; Zacharewski, Tim.

Afiliación

Orlowska K; Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
Fling RR; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA; Microbiology & Molecular Genetics, Michigan Sptate University, East Lansing, Michigan, USA.
Nault R; Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
Sink WJ; Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
Schilmiller AL; Mass Spectrometry and Metabolomics Core, Michigan State University, East Lansing, Michigan, USA.
Zacharewski T; Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA. Electronic address: tzachare@msu.edu.

J Biol Chem ; 298(9): 102301, 2022 09.

Article en En | MEDLINE | ID: mdl-35931118

Asunto(s)

Acilcoenzima A; Contaminantes Ambientales; Hígado Graso; Hígado; Dibenzodioxinas Policloradas; Deficiencia de Vitamina B 12; Vitamina B 12; Ácido Aconítico/metabolismo; Acilcoenzima A/metabolismo; Animales; Cobalto/metabolismo; Cisteína/metabolismo; Contaminantes Ambientales/toxicidad; Hígado Graso/inducido químicamente; Hígado Graso/metabolismo; Humanos; Hígado/efectos de los fármacos; Hígado/metabolismo; Metilmalonil-CoA Mutasa/genética; Metilmalonil-CoA Mutasa/metabolismo; Ratones; Dibenzodioxinas Policloradas/toxicidad; Receptores de Hidrocarburo de Aril/metabolismo; Succinatos/metabolismo; Vitamina B 12/metabolismo; Deficiencia de Vitamina B 12/inducido químicamente; Deficiencia de Vitamina B 12/complicaciones

Palabras clave

acrylyl-CoA; dioxin; gene expression; liver; metabolism; mouse

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vitamina B 12 / Deficiencia de Vitamina B 12 / Acilcoenzima A / Contaminantes Ambientales / Hígado Graso / Dibenzodioxinas Policloradas / Hígado Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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