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Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments.
Gan, Lei; Velásquez-Hernández, Miriam de J; Emmerstorfer-Augustin, Anita; Wied, Peter; Wolinski, Heimo; Zilio, Simone Dal; Solomon, Marcello; Liang, Weibin; Doonan, Christian; Falcaro, Paolo.
Afiliación
  • Gan L; Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
  • Velásquez-Hernández MJ; Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
  • Emmerstorfer-Augustin A; Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, BioTechMed-Graz,, Petergasse 14, Graz, 8010, Austria.
  • Wied P; Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
  • Wolinski H; Institute of Molecular Biosciences, BioTechMed-Graz, University of Graz, Graz, Austria.
  • Zilio SD; Istituto Officina dei Materiali CNR, Basovizza, Edificio MM-SS, Trieste, Italy.
  • Solomon M; Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
  • Liang W; School of Physical Sciences, Faculty of Sciences, University of Adelaide, South Australia, 5005, Australia. christian.doonan@adelaide.edu.au.
  • Doonan C; School of Physical Sciences, Faculty of Sciences, University of Adelaide, South Australia, 5005, Australia. christian.doonan@adelaide.edu.au.
  • Falcaro P; Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
Chem Commun (Camb) ; 58(72): 10004-10007, 2022 Sep 08.
Article en En | MEDLINE | ID: mdl-35942713
ABSTRACT
Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estructuras Metalorgánicas / Antineoplásicos Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estructuras Metalorgánicas / Antineoplásicos Idioma: En Año: 2022 Tipo del documento: Article