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Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.
Datta, Jashodeep; Dai, Xizi; Bianchi, Anna; De Castro Silva, Iago; Mehra, Siddharth; Garrido, Vanessa T; Lamichhane, Purushottam; Singh, Samara P; Zhou, Zhiqun; Dosch, Austin R; Messaggio, Fanuel; Ban, Yuguang; Umland, Oliver; Hosein, Peter J; Nagathihalli, Nagaraj S; Merchant, Nipun B.
Afiliación
  • Datta J; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
  • Dai X; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Bianchi A; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • De Castro Silva I; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Mehra S; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Garrido VT; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Lamichhane P; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida; Clovis Oncology, Boulder, Colorado.
  • Singh SP; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Zhou Z; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Dosch AR; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Messaggio F; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
  • Ban Y; Bioinformatics and Biostatistics Shared Resource, Sylvester Comprehensive Cancer Center, Miami, Florida.
  • Umland O; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida.
  • Hosein PJ; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.
  • Nagathihalli NS; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida.
  • Merchant NB; Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida. Electronic address: nmerchant@med.miami.edu.
Gastroenterology ; 163(6): 1593-1612, 2022 12.
Article en En | MEDLINE | ID: mdl-35948109
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático / Células Madre Mesenquimatosas / Fibroblastos Asociados al Cáncer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Carcinoma Ductal Pancreático / Células Madre Mesenquimatosas / Fibroblastos Asociados al Cáncer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article