Homeostasis limits keratinocyte evolution.

Schenck, Ryan O; Kim, Eunjung; Bravo, Rafael R; West, Jeffrey; Leedham, Simon; Shibata, Darryl; Anderson, Alexander R A

Schenck, Ryan O; Kim, Eunjung; Bravo, Rafael R; West, Jeffrey; Leedham, Simon; Shibata, Darryl; Anderson, Alexander R A.

Afiliación

Schenck RO; Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.
Kim E; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
Bravo RR; Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.
West J; Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.
Leedham S; Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.
Shibata D; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
Anderson ARA; Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033.

Proc Natl Acad Sci U S A ; 119(35): e2006487119, 2022 08 30.

Article en En | MEDLINE | ID: mdl-35998218

Asunto(s)

Evolución Clonal; Epidermis; Homeostasis; Queratinocitos; Carcinogénesis/genética; Evolución Clonal/genética; Epidermis/metabolismo; Humanos; Queratinocitos/citología; Queratinocitos/fisiología; Mutación; Receptor Notch1/genética; Proteína p53 Supresora de Tumor/genética

Palabras clave

carcinogenesis; keratinocyte biology; mathematical modeling; somatic evolution

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Queratinocitos / Epidermis / Evolución Clonal / Homeostasis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

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