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Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.
Lesniak, Robert K; Nichols, R Jeremy; Schonemann, Marcus; Zhao, Jing; Gajera, Chandresh R; Lam, Grace; Nguyen, Khanh C; Langston, J William; Smith, Mark; Montine, Thomas J.
Afiliación
  • Lesniak RK; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA. Electronic address: r.k.lesniak@stanford.edu.
  • Nichols RJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Schonemann M; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Zhao J; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Gajera CR; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
  • Lam G; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Nguyen KC; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Langston JW; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA; Department of Neurology and Neuroscience, 300 Pasteur Drive, Stanford University, Stanford, CA, 94304, USA.
  • Smith M; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA.
  • Montine TJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
Eur J Med Chem ; 242: 114693, 2022 Nov 15.
Article en En | MEDLINE | ID: mdl-36049274
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article