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DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.
Parzych, Elizabeth M; Du, Jianqiu; Ali, Ali R; Schultheis, Katherine; Frase, Drew; Smith, Trevor R F; Cui, Jiayan; Chokkalingam, Neethu; Tursi, Nicholas J; Andrade, Viviane M; Warner, Bryce M; Gary, Ebony N; Li, Yue; Choi, Jihae; Eisenhauer, Jillian; Maricic, Igor; Kulkarni, Abhijeet; Chu, Jacqueline D; Villafana, Gabrielle; Rosenthal, Kim; Ren, Kuishu; Francica, Joseph R; Wootton, Sarah K; Tebas, Pablo; Kobasa, Darwyn; Broderick, Kate E; Boyer, Jean D; Esser, Mark T; Pallesen, Jesper; Kulp, Dan W; Patel, Ami; Weiner, David B.
Afiliación
  • Parzych EM; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Du J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Ali AR; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Schultheis K; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Frase D; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Cui J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Chokkalingam N; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Tursi NJ; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Andrade VM; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Warner BM; Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.
  • Gary EN; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Li Y; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Choi J; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Eisenhauer J; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Kulkarni A; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Chu JD; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Villafana G; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Rosenthal K; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.
  • Ren K; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.
  • Francica JR; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.
  • Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada.
  • Tebas P; University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Kobasa D; Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.
  • Broderick KE; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada.
  • Boyer JD; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Esser MT; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
  • Pallesen J; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA.
  • Kulp DW; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.
  • Patel A; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
  • Weiner DB; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA.
Nat Commun ; 13(1): 5886, 2022 10 06.
Article en En | MEDLINE | ID: mdl-36202799

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Productos Biológicos / Ácidos Nucleicos / COVID-19 Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Productos Biológicos / Ácidos Nucleicos / COVID-19 Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article