Synthesis and Theoretical Studies of Biologically Active Thieno Nucleus Incorporated Tri and Tetracyclic Nitrogen Containing Heterocyclics Scaffolds via Suzuki Cross-Coupling Reaction.
Chem Biodivers
; 19(12): e202200540, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36310125
ABSTRACT
A new series of thieno nucleus embellished trinuclear (19, 20) and tetranuclear (21-24) nitrogen heteroaryl have been synthesized by the Suzuki cross-coupling reaction using bis(triphenylphosphine)palladium(II) dichloride. All the synthesized compounds were characterized by IR, 1 H-NMR, 13 CNMR and Mass spectral properties. Inâ
vitro antibacterial studies of the synthesized compound were conducted using broth microdilution assay employing Gram-positive and Gram-negative strains and half-maximal inhibitory concentration (IC50 ) was determined. The result showed that compound 20 possess best antibacterial activity against S.â
aureus and E.â
coli with IC50 values of 60â
µg mL-1 and 90â
µg mL-1 . Further to determine the mode of antibacterial action, compounds 20 and 21 were examined for inâ
vitro bacterial dehydrogenase inhibitory assay. To understand the binding affinity of the synthesized compounds, the docking study was performed in the bacterial dehydrogenase enzyme by AutoDock Vina software and structure was confirmed by Discovery Studio Visualizer. All the synthesized compounds were docked in a good manner within the active sites of the bacterial dehydrogenase enzyme and exhibited good binding energies.
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MEDLINE
Asunto principal:
Staphylococcus aureus
/
Nitrógeno
Idioma:
En
Año:
2022
Tipo del documento:
Article