A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia.
Acta Radiol
; 64(4): 1573-1578, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-36317293
ABSTRACT
BACKGROUND:
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Bone marrow computed tomography (CT) attenuation may increase in patients with myeloproliferative disorders; however, the actual threshold CT attenuation value predictive of myeloproliferative has not been reported.PURPOSE:
To determine whether the unenhanced CT attenuation value of the bone marrow may be useful for predicting AML. MATERIAL ANDMETHODS:
We retrospectively analyzed patients with AML (n = 56) who underwent unenhanced CT before treatment, and age- and sex-matched controls without any hematologic disease. For each patient, the CT attenuation value (HU) of the iliac bone was measured and compared between the two groups. Receiver operating characteristic (ROC) curve analysis was used to define the cutoff value for predicting AML on all patients, and only on late elderly patients (aged ≥75 years).RESULTS:
Patients with AML showed higher bone marrow CT attenuation value (131.4 ± 58.3 vs. 53.9 ± 67.2 HU; P < 0.001), compared to the controls. The sensitivity and specificity for the diagnosis of AML in all patients were 78.6% and 80.4%, respectively, at a threshold value of 90 HU, whereas they were 83.3% and 91.7%, respectively, at 40 HU in late elderly patients.CONCLUSION:
The iliac bone CT attenuation value was elevated in patients with AML and may be useful for predicting AML.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Médula Ósea
/
Leucemia Mieloide Aguda
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article