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RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.
Spencer-Smith, Russell; Terrell, Elizabeth M; Insinna, Christine; Agamasu, Constance; Wagner, Morgan E; Ritt, Daniel A; Stauffer, Jim; Stephen, Andrew G; Morrison, Deborah K.
Afiliación
  • Spencer-Smith R; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA.
  • Terrell EM; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA.
  • Insinna C; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA.
  • Agamasu C; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702 USA.
  • Wagner ME; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702 USA.
  • Ritt DA; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA.
  • Stauffer J; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA.
  • Stephen AG; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702 USA.
  • Morrison DK; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 USA. Electronic address: morrisod@mail.nih.gov.
Mol Cell ; 82(22): 4262-4276.e5, 2022 11 17.
Article en En | MEDLINE | ID: mdl-36347258
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cisteína / Proteínas Proto-Oncogénicas B-raf Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cisteína / Proteínas Proto-Oncogénicas B-raf Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article