De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019.
J Infect Public Health
; 15(12): 1455-1458, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36403401
ABSTRACT
The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antígenos de Grupos Sanguíneos
/
COVID-19
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article