D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review.

Wauthier, Loris; Favresse, Julien; Hardy, Michaël; Douxfils, Jonathan; Le Gal, Grégoire; Roy, Pierre-Marie; van Es, Nick; Ay, Cihan; Ten Cate, Hugo; Vander Borght, Thierry; Dupont, Michaël V; Lecompte, Thomas; Lippi, Giuseppe; Mullier, François

Wauthier, Loris; Favresse, Julien; Hardy, Michaël; Douxfils, Jonathan; Le Gal, Grégoire; Roy, Pierre-Marie; van Es, Nick; Ay, Cihan; Ten Cate, Hugo; Vander Borght, Thierry; Dupont, Michaël V; Lecompte, Thomas; Lippi, Giuseppe; Mullier, François.

Afiliación

Wauthier L; Department of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Favresse J; Department of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Namur, Belgium.
Hardy M; Department of Pharmacy, Namur Research Institute for Life Sciences, University of Namur, 5000 Namur, Belgium.
Douxfils J; Namur Thrombosis and Hemostasis Center (NTHC), CHU UCL Namur, Université Catholique de Louvain, 5530 Yvoir, Belgium.
Le Gal G; Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium.
Roy PM; QUALIblood s.a., 5000 Namur, Belgium.
van Es N; Department of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Ay C; Department of Emergency Medicine, CHU Angers, Institut MITOVASC, Equipe CARME, UMR CNRS 6015-INSERM 1083, UNIV Angers, F-CRIN INNOVTE, 49000 Angers, France.
Ten Cate H; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension & Thrombosis, Amsterdam UMC Location Universiteit van Amsterdam, 1105 Amsterdam, The Netherlands.
Vander Borght T; Department of Vascular Medicine, Amsterdam UMC Location Universiteit van Amsterdam, 1105 Amsterdam, The Netherlands.
Dupont MV; Clinicial Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Lecompte T; Department of Internal Medicine and Thrombosis Expertise Center, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
Lippi G; Center for Thrombosis and Hemostasis, Gutenberg University Medical Center, 55131 Mainz, Germany.
Mullier F; Department of Nuclear Medicine, CHU UCL Namur, 5530 Yvoir, Belgium.

Diagnostics (Basel) ; 12(11)2022 Nov 12.

Article en En | MEDLINE | ID: mdl-36428830

ABSTRACT

ABSTRACT

D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.

Palabras clave

D-dimer; ISO15189; In Vitro Diagnostic Regulation; analytical; post-analytical; pre-analytical; pulmonary embolism; venous thromboembolism

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