Foxp3+ regulatory T cell therapy for tolerance in autoimmunity and solid organ transplantation.
Front Immunol
; 13: 1055466, 2022.
Article
en En
| MEDLINE
| ID: mdl-36466912
ABSTRACT
Regulatory T cells (Tregs) are critical for tolerance in humans. The exact mechanisms by which the loss of peripheral tolerance leads to the development of autoimmunity and the specific role Tregs play in allograft tolerance are not fully understood; however, this population of T cells presents a unique opportunity in the development of targeted therapeutics. In this review, we discuss the potential roles of Foxp3+ Tregs in the development of tolerance in transplantation and autoimmunity, and the available data regarding their use as a treatment modality.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Autoinmunidad
/
Trasplante de Órganos
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article