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Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures.
Minarrieta, Lucía; Godoy, Gloria J; Velazquez, Lis N; Ghorbani, Peyman; Sparwasser, Tim; Berod, Luciana.
Afiliación
  • Minarrieta L; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada.
  • Godoy GJ; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Velazquez LN; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Ghorbani P; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada.
  • Sparwasser T; Institute of Medical Microbiology and Hygiene, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Berod L; Research Center for Immunotherapy (FZI), University Medical Center Mainz, Mainz, Germany.
Eur J Immunol ; 53(2): e2149691, 2023 02.
Article en En | MEDLINE | ID: mdl-36577714
ABSTRACT
The CD11c+ MHCII+ compartment within GM-CSF cultures consists of a MHCIIlow CD11bhigh population (GM-Macs) and a MHCIIhigh CD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor Estimulante de Colonias de Granulocitos y Macrófagos / Óxido Nítrico Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor Estimulante de Colonias de Granulocitos y Macrófagos / Óxido Nítrico Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article