Phosphine-catalysed denitrative rearomatising (3 + 2) annulation of α,ß-ynones and 3-nitroindoles.
Org Biomol Chem
; 21(4): 738-742, 2023 Jan 25.
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| MEDLINE
| ID: mdl-36601997
ABSTRACT
We describe a metal-free strategy to access various α-arylidene cyclopenta[b]indoles via phosphine-catalysed (3 + 2) annulation of α,ß-ynones and 3-nitroindoles. For the first time, the rearomatisation of the indole nucleus was observed in such an annulative transformation. The method was extended to the synthesis of an antimalarial natural product, bruceolline E.
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2023
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